Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diaryl-pyrazines via a cascade process

被引：9
|
作者：
Liu, Cong [1 ]
Dai, Rong J. [1 ]
Yao, Guo W. [1 ]
Deng, Yu L. [1 ]
机构：
[1] Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China
来源：
ARKIVOC | 2014年
关键词：
Debus-Radziszewski condensation; cascade reactions; imidazole synthesis; DMSO-HBr oxidation; pyrazine synthesis; ONE-POT SYNTHESIS; ALKALOIDS; KETONES; IDENTIFICATION; DERIVATIVES; PROTEINS; INDOLE;
D O I：
10.3998/ark.5550190.p008.270
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of (4 or 5)-aryl-2-aroyl-1H-imidazoles and 2-hydroxy-3,6-diarylpyrazines from aryl methyl ketones via a cascade process of DMSO-HBr oxidation and Debus reaction was investigated. Owing to the simple starting materials, mild conditions, easy operation, high bioactivity of imidazole and pyrazine derivatives, this protocol has great potential in medicinal chemistry.
引用
收藏
页码：146 / 163
页数：18
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