SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 1-[2-(4-AMINOSULFONYLPHENYL)ETHYL]-5-ARYL-4-AROYL-3-HYDROXY-3-PYRROLIN-2-ONES

被引：4
|
作者：
Gein, V. L. [1 ]
Bobrovskaya, O. V. [1 ]
Valiev, R. T. [1 ]
Odegova, T. F. [1 ]
Gartman, G. A. [2 ]
机构：
[1] Minist Hlth Russian Federat, Perm State Pharmaceut Acad, 2 Polevaya St, Perm 614990, Russia
[2] Perm State Natl Res Univ, Perm, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2015年 / 49卷 / 09期
关键词：
1-[2-(4-aminosulfonylphenyl)ethyl]-5-aryl-4-aroyl-3-hydroxy-3-pyrrolin-2-ones; synthesis; antibacterial activity;
D O I：
10.1007/s11094-015-1337-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Reaction of the methyl esters of aroylpyruvic acids with mixtures of 4-(2-aminoethyl)benzenesulfonamide and an aromatic aldehyde was used to synthesize 1-[2-(4-aminosulfonylphenyl)ethyl]-5-aryl-4-aroyl-3-hydroxy-3-pyrrolin-2-ones. The structures of these compounds were verified by IR and H-1 NMR spectroscopy and mass spectrometry. Their antibacterial activity was studied.
引用
收藏
页码：602 / 604
页数：3
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