SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 1-[2-(4-AMINOSULFONYLPHENYL)ETHYL]-5-ARYL-4-AROYL-3-HYDROXY-3-PYRROLIN-2-ONES

被引：4

作者：

Gein, V. L. ^{[1
]}

Bobrovskaya, O. V. ^{[1
]}

Valiev, R. T. ^{[1
]}

Odegova, T. F. ^{[1
]}

Gartman, G. A. ^{[2
]}

机构：

[1] Minist Hlth Russian Federat, Perm State Pharmaceut Acad, 2 Polevaya St, Perm 614990, Russia

[2] Perm State Natl Res Univ, Perm, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2015年 / 49卷 / 09期

关键词：

1-[2-(4-aminosulfonylphenyl)ethyl]-5-aryl-4-aroyl-3-hydroxy-3-pyrrolin-2-ones; synthesis; antibacterial activity;

D O I：

10.1007/s11094-015-1337-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Reaction of the methyl esters of aroylpyruvic acids with mixtures of 4-(2-aminoethyl)benzenesulfonamide and an aromatic aldehyde was used to synthesize 1-[2-(4-aminosulfonylphenyl)ethyl]-5-aryl-4-aroyl-3-hydroxy-3-pyrrolin-2-ones. The structures of these compounds were verified by IR and H-1 NMR spectroscopy and mass spectrometry. Their antibacterial activity was studied.

引用

页码：602 / 604

页数：3

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