Synthesis and Antiinflammatory and Analgesic Activity of 1-(2-aminoethyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones

被引：0
|
作者：
V. L. Gein
V. V. Yushkov
N. N. Kasimova
N. S. Shuklina
M. Yu. Vasil'eva
M. V. Gubanova
机构：
[1] Perm State Pharmaceutical Academy,
来源：
Pharmaceutical Chemistry Journal | 2005年 / 39卷
关键词：
Methyl; Ester; Organic Chemistry; Aldehyde; Methyl Ester;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
4,5-Disubstituted 1-(2-aminoethyl)-3-hydroxy-3-pyrrolin-2-ones have been synthesized via reactions of acylpyruvic acid methyl esters with a mixture of an aromatic aldehyde and ethylenediamine. Some of the synthesized compounds display pronounced antiinflammatory and analgesic activity at a relatively low toxicity.
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页码：484 / 487
页数：3
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