Synthesis and Analgesic and Antibacterial Activity of 5-aryl-4-aroyl-1-(4-acetylaminosulfonylphenyl)-3-hydroxy-3-pyrrolin-2-ones

被引:4
|
作者
Gein, V. L. [1 ]
Bobrovskaya, O. V. [1 ]
Seliverstov, G. V. [1 ]
Makhmudov, R. R. [2 ]
Novikova, V. V. [1 ]
机构
[1] Perm State Pharmaceut Acad, Minist Hlth Russian Federat, 2 Polevaya St, Perm 614900, Russia
[2] Perm State Natl Res Univ, Perm, Russia
关键词
5-aryl-4-aroyl-1-(4-acetylaminosulfonylphenyl)-3-hydroxy-3-pyrrolin-2-ones; synthesis; analgesic and antibacterial activity;
D O I
10.1007/s11094-017-1579-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A three-component reaction of aroylpyruvic acid methyl ester with a mixture of an aromatic aldehyde and 4-aminobenzenesulfonylacetamide (sulfacetamide) was used to synthesize 5-aryl-4-aroyl-1-(4-acetylaminosulfonylphenyl)-3-hydroxy-3-pyrrolin-2-ones. The structures of these compounds were established by IR, NMR, and H-1 spectroscopy, along with mass spectrometry. The analgesic and antibacterial activities of these compounds were studied.
引用
收藏
页码:187 / 190
页数:4
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