Synthesis and Analgesic and Antibacterial Activity of 5-aryl-4-aroyl-1-(4-acetylaminosulfonylphenyl)-3-hydroxy-3-pyrrolin-2-ones

被引：4

作者：

Gein, V. L. ^{[1
]}

Bobrovskaya, O. V. ^{[1
]}

Seliverstov, G. V. ^{[1
]}

Makhmudov, R. R. ^{[2
]}

Novikova, V. V. ^{[1
]}

机构：

[1] Perm State Pharmaceut Acad, Minist Hlth Russian Federat, 2 Polevaya St, Perm 614900, Russia

[2] Perm State Natl Res Univ, Perm, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2017年 / 51卷 / 03期

关键词：

5-aryl-4-aroyl-1-(4-acetylaminosulfonylphenyl)-3-hydroxy-3-pyrrolin-2-ones; synthesis; analgesic and antibacterial activity;

D O I：

10.1007/s11094-017-1579-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A three-component reaction of aroylpyruvic acid methyl ester with a mixture of an aromatic aldehyde and 4-aminobenzenesulfonylacetamide (sulfacetamide) was used to synthesize 5-aryl-4-aroyl-1-(4-acetylaminosulfonylphenyl)-3-hydroxy-3-pyrrolin-2-ones. The structures of these compounds were established by IR, NMR, and H-1 spectroscopy, along with mass spectrometry. The analgesic and antibacterial activities of these compounds were studied.

引用

页码：187 / 190

页数：4

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