Synthesis and biological activity of 5-aryl-4-acyl-3-hydroxy-1- morpholinoalkyl-3-pyrrolin-2-ones

被引：0
|
作者：
Gein V.L. [1 ]
Yushkov V.V. [1 ]
Kasimova N.N. [1 ]
Voronina E.V. [1 ]
Rakshina N.S. [1 ]
Vasil'eva M.Yu. [1 ]
机构：
[1] Perm State Pharmaceutical Academy, Perm
来源：
Pharmaceutical Chemistry Journal | 2007年 / 41卷 / 5期
基金：
俄罗斯基础研究基金会;
关键词：
Aromatic Aldehyde; Piracetam; Analgin; Ethacridine Lactate; Perm State Pharmaceutical Academy;
D O I：
10.1007/s11094-007-0057-7
中图分类号：
学科分类号：
摘要：
A series of 5-aryl-4-acyl-3-hydroxy-1-morpholinoalkyl-3-pyrroline-2-ones was synthesized via the reactions of methyl esters of acylpyruvic acids with a mixture of aromatic aldehyde and 2-(4-morpholino)-1-ethylamine or 3-(4-morpholino)-1-propylamine. All compounds possess weak antibacterial properties. The antiamnesic, analgesic, and antiphlogistic activity and acute toxicity of several compounds were studied. It was established that one compound produced a significant antiamnesic effect and two compounds exhibited pronounced analgesic activity. © 2007 Springer Science+Business Media, Inc.
引用
收藏
页码：256 / 263
页数：7
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