Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)-5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives

被引：4
|
作者：
Gein, V. L. [1 ]
Kasimova, N. N. [1 ]
Chashchina, S., V [1 ]
Starkova, A., V [1 ]
Syropyatov, B. Ya [1 ]
机构：
[1] Minist Hlth RF, Perm State Pharmaceut Acad, 2 Polevaya St, Perm 614990, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2019年 / 53卷 / 08期
关键词：
4-acyl-1-(2-aminopropyl)-5-aryl-3-hydroxy-3-pyrrolin-2-ones; pyrrolo[3; 4-c]pyrazole; synthesis; anti-inflammatory activity; analgesic activity; hemostatic effect;
D O I：
10.1007/s11094-019-02066-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 1-(2-aminopropyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by three-component reactions of 4-substituted 2,4-dioxobutanoic acid methyl esters with mixtures of an aromatic aldehyde and 1,2-diaminopropane. Products of their reactions with hydrazine, p-phenetidine, and acetic anhydride were obtained. The analgesic, anti-inflammatory, and antimicrobial activities and hemostatic effect of several compounds were studied.
引用
收藏
页码：701 / 705
页数：5
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