Anti-Inflammatory Activity of 5-Aryl-4-Hetaroyl-3-Hydroxy-1-Hydroxyalkyl-3-Pyrrolin-2-Ones

被引：0

作者：

Gein, O. N. ^{[1
]}

Mazunina, I. M. ^{[1
]}

Gein, V. S. ^{[2
]}

Rubtsova, D. D. ^{[1
]}

Gein, V. L. ^{[1
]}

机构：

[1] Minist Hlth Russian Federat, Perm State Pharmaceut Acad, 2 Polevaya St, Perm 614990, Russia

[2] Perm State Natl Res Univ, 15 Bukireva St, Perm 614068, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2024年 / 58卷 / 08期

关键词：

anti-inflammatory activity; analgesic activity; pyrrolin-2-ones; 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-ones; phagocytosis; PYRROLIDINE-2,3-DIONES; INFLAMMATION;

D O I：

10.1007/s11094-024-03268-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The anti-inflammatory activity of new 3-pyrrolin-2-one derivatives, namely, 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-ones, was studied. The studied 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-ones exhibited an anti-inflammatory effect, inhibiting swelling of rat paws in an acute exudative inflammation model caused by subplantar injection of carrageenan solution (1%) and did not change the absorption activity of peripheral blood leukocytes. The studied compounds reduced the number of abdominal muscle contractions in mice in a peritovisceral pain model caused by intraperitoneal injection of acetic-acid solution (0.75%).

引用

页码：1263 / 1266

页数：4

共 50 条

[1] Acute Toxicity and Analgesic Activity of 5-Aryl-4-Hetaroyl-3-Hydroxy-1-Hydroxyalkyl-3-Pyrrolin-2-Ones
O. N. Gein
D. D. Rubtsova
V. L. Gein
Pharmaceutical Chemistry Journal, 2023, 56 : 1604 - 1606
[2] Acute Toxicity and Analgesic Activity of 5-Aryl-4-Hetaroyl-3-Hydroxy-1-Hydroxyalkyl-3-Pyrrolin-2-Ones
Gein, O. N.
Rubtsova, D. D.
Gein, V. L.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2023, 56 (12) : 1604 - 1606
[3] Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-Aroyl-3-Hydroxy-1-Carboxymethyl-3-Pyrrolin-2-Ones
E. V. Pastukhova
S. V. Chashchina
A. S. Ivanova
E. E. Petrova
V. L. Gein
Pharmaceutical Chemistry Journal, 2022, 56 : 1188 - 1191
[4] Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-Aroyl-3-Hydroxy-1-Carboxymethyl-3-Pyrrolin-2-Ones
Pastukhova, E. V.
Chashchina, S. V.
Ivanova, A. S.
Petrova, E. E.
Gein, V. L.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2022, 56 (09) : 1188 - 1191
[5] Anti-inflammatory and analgesic activity of 5-aryl-4-acyl-1-heteryl-3- hydroxy-3-pyrrolin-2-ones
Gein V.L.
Yushkov V.V.
Splina T.A.
Gein L.F.
Yatsenko K.V.
Shevtsova S.G.
Pharmaceutical Chemistry Journal, 2008, 42 (5) : 255 - 257
[6] Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1-Carboxymethyl-3-Pyrrolin-2-Ones
Pastukhova, E. V.
Chashchina, S. V.
Buldakova, E. A.
Gein, V. L.
Mokrushin, I. G.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2023,
[7] Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1-Carboxymethyl-3-PyrroliN-2-Ones
E. V. Pastukhova
S. V. Chashchina
E. A. Buldakova
V. L. Gein
I. G. Mokrushin
Pharmaceutical Chemistry Journal, 2023, 57 (2) : 204 - 208
[8] Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1-Carboxymethyl-3-PyrroliN-2-Ones
Pastukhova, E. V.
Chashchina, S. V.
Buldakova, E. A.
Gein, V. L.
Mokrushin, I. G.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2023, 57 (02) : 204 - 208
[9] Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)- 5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives
V. L. Gein
N. N. Kasimova
S. V. Chashchina
A. V. Starkova
B. Ya. Syropyatov
Pharmaceutical Chemistry Journal, 2019, 53 : 701 - 705
[10] Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)-5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives
Gein, V. L.
Kasimova, N. N.
Chashchina, S., V
Starkova, A., V
Syropyatov, B. Ya
PHARMACEUTICAL CHEMISTRY JOURNAL, 2019, 53 (08) : 701 - 705

← 1 2 3 4 5 →