Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)- 5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives

被引：0
|
作者：
V. L. Gein
N. N. Kasimova
S. V. Chashchina
A. V. Starkova
B. Ya. Syropyatov
机构：
[1] Ministry of Health of the RF,Perm State Pharmaceutical Academy
来源：
Pharmaceutical Chemistry Journal | 2019年 / 53卷
关键词：
4-acyl-1-(2-aminopropyl)-5-aryl-3-hydroxy-3-pyrrolin-2-ones; pyrrolo[3; 4-; ]pyrazole; synthesis; anti-inflammatory activity; analgesic activity; hemostatic effect;
D O I：
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中图分类号：
学科分类号：
摘要：
A series of 1-(2-aminopropyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by three-component reactions of 4-substituted 2,4-dioxobutanoic acid methyl esters with mixtures of an aromatic aldehyde and 1,2-diaminopropane. Products of their reactions with hydrazine, p-phenetidine, and acetic anhydride were obtained. The analgesic, anti-inflammatory, and antimicrobial activities and hemostatic effect of several compounds were studied.
引用
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页码：701 / 705
页数：4
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