Anti-inflammatory and analgesic activity of 5-aryl-4-acyl-1-heteryl-3- hydroxy-3-pyrrolin-2-ones

被引：2
|
作者：
Gein V.L. [1 ]
Yushkov V.V. [1 ]
Splina T.A. [1 ]
Gein L.F. [1 ]
Yatsenko K.V. [1 ]
Shevtsova S.G. [1 ]
机构：
[1] State Educational Institution of Higher Professional Education Perm State Pharmaceutical Academy, Russian Ministry of Health, Perm State Medical Academy, Perm
来源：
Pharmaceutical Chemistry Journal | 2008年 / 42卷 / 5期
基金：
俄罗斯基础研究基金会;
关键词：
Glacial Acetic Acid; Analgesic Activity; Inflammatory Edema; Analgin; Ketone Carbonyl Group;
D O I：
10.1007/s11094-008-0100-3
中图分类号：
学科分类号：
摘要：
A three-component reaction of acetylpyruvic acid esters, aromatic aldehydes, and heterylamines was used to synthesize 3-hydroxy-3-pyrrolin-2-ones containing heterocyclic substituents at the 1 position of the pyrroline ring. The effects of the heterocyclic substituent on the extent of anti-inflammatory and analgesic actions were studied. © 2008 Springer Science+Business Media, Inc.
引用
收藏
页码：255 / 257
页数：2
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