Anti-Inflammatory Activity of 5-Aryl-4-Hetaroyl-3-Hydroxy-1-Hydroxyalkyl-3-Pyrrolin-2-Ones

被引：0

作者：

Gein, O. N. ^{[1
]}

Mazunina, I. M. ^{[1
]}

Gein, V. S. ^{[2
]}

Rubtsova, D. D. ^{[1
]}

Gein, V. L. ^{[1
]}

机构：

[1] Minist Hlth Russian Federat, Perm State Pharmaceut Acad, 2 Polevaya St, Perm 614990, Russia

[2] Perm State Natl Res Univ, 15 Bukireva St, Perm 614068, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2024年 / 58卷 / 08期

关键词：

anti-inflammatory activity; analgesic activity; pyrrolin-2-ones; 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-ones; phagocytosis; PYRROLIDINE-2,3-DIONES; INFLAMMATION;

D O I：

10.1007/s11094-024-03268-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The anti-inflammatory activity of new 3-pyrrolin-2-one derivatives, namely, 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-ones, was studied. The studied 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-ones exhibited an anti-inflammatory effect, inhibiting swelling of rat paws in an acute exudative inflammation model caused by subplantar injection of carrageenan solution (1%) and did not change the absorption activity of peripheral blood leukocytes. The studied compounds reduced the number of abdominal muscle contractions in mice in a peritovisceral pain model caused by intraperitoneal injection of acetic-acid solution (0.75%).

引用

页码：1263 / 1266

页数：4

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