Anti-Inflammatory Activity of 5-Aryl-4-Hetaroyl-3-Hydroxy-1-Hydroxyalkyl-3-Pyrrolin-2-Ones

被引：0

作者：

Gein, O. N. ^{[1
]}

Mazunina, I. M. ^{[1
]}

Gein, V. S. ^{[2
]}

Rubtsova, D. D. ^{[1
]}

Gein, V. L. ^{[1
]}

机构：

[1] Minist Hlth Russian Federat, Perm State Pharmaceut Acad, 2 Polevaya St, Perm 614990, Russia

[2] Perm State Natl Res Univ, 15 Bukireva St, Perm 614068, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2024年 / 58卷 / 08期

关键词：

anti-inflammatory activity; analgesic activity; pyrrolin-2-ones; 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-ones; phagocytosis; PYRROLIDINE-2,3-DIONES; INFLAMMATION;

D O I：

10.1007/s11094-024-03268-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The anti-inflammatory activity of new 3-pyrrolin-2-one derivatives, namely, 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-ones, was studied. The studied 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-ones exhibited an anti-inflammatory effect, inhibiting swelling of rat paws in an acute exudative inflammation model caused by subplantar injection of carrageenan solution (1%) and did not change the absorption activity of peripheral blood leukocytes. The studied compounds reduced the number of abdominal muscle contractions in mice in a peritovisceral pain model caused by intraperitoneal injection of acetic-acid solution (0.75%).

引用

页码：1263 / 1266

页数：4

共 50 条

[21] Synthesis and antimicrobial activity of 1-(4-hydroxyphenyl)-4-acyl-5-aryl-3-hydroxy-3-pyrrolin-2-ones
V. L. Gein
M. N. Armisheva
N. A. Rassudikhina
M. I. Vakhrin
E. V. Voronina
Pharmaceutical Chemistry Journal, 2011, 45 : 162 - 164
[22] Synthesis and Antibacterial Activity of 1-(4-Aminosulfonylphenyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones
V. L. Gein
T. F. Odegova
K. A. Tkachenko
O. V. Bobrovskaya
M. I. Vakhrin
Pharmaceutical Chemistry Journal, 2013, 47 : 371 - 373
[23] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1-(4-HYDROXYPHENYL)-4-ACYL-5-ARYL-3-HYDROXY-3-PYRROLIN-2-ONES
Gein, V. L.
Armisheva, M. N.
Rassudikhina, N. A.
Vakhrin, M. I.
Voronina, E. V.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2011, 45 (03) : 162 - 164
[24] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 1-(4-AMINOSULFONYLPHENYL)-5-ARYL-4-ACYL-3-HYDROXY-3-PYRROLIN-2-ONES
Gein, V. L.
Odegova, T. F.
Tkachenko, K. A.
Bobrovskaya, O. V.
Vakhrin, M. I.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2013, 47 (07) : 371 - 373
[25] Synthesis and biological activity of 4-acyl-5-aryl-3-hydroxy-1-(2- hydroxyethylaminoethyl)-3-pyrrolin-2-ones
Gein V.L.
Kasimova N.N.
Moiseev A.L.
Sheptukha M.A.
Syropyatov B.Ya.
Ismailova N.G.
Voronina E.V.
Ivanenko O.I.
Pharmaceutical Chemistry Journal, 2007, 41 (9) : 476 - 479
[26] Synthesis and antibacterial activity of 5-aryl-4-acyl-3-hydroxy-1-(2-hydroxyethyl)-3-pyrrolin-2-ones
Gein, V. L.
Odegova, T. F.
Korol', A. N.
Varkentin, L. I.
Bobyleva, A. A.
Gein, L. F.
Vakhrin, M. I.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2014, 47 (10) : 536 - 538
[27] Synthesis and antibacterial activity of 5-aryl-4-acyl-3-hydroxy-1-(2-hydroxyethyl)-3-pyrrolin-2-ones
V. L. Gein
T. F. Odegova
A. N. Korol’
L. I. Varkentin
A. A. Bobyleva
L. F. Gein
M. I. Vakhrin
Pharmaceutical Chemistry Journal, 2014, 47 : 536 - 538
[28] Synthesis of 5-aryl-4-aroyl-3-hydroxy-1-(4-guanidylsulfonylphenyl)-3-pyrrolin-2-ones
V. L. Gein
I. V. Kovtonogova
O. V. Bobrovskaya
M. I. Vakhrin
Russian Journal of General Chemistry, 2014, 84 : 264 - 267
[29] Synthesis of 5-aryl-4-aroyl-3-hydroxy-1-(4-guanidylsulfonylphenyl)-3-pyrrolin-2-ones
Gein, V. L.
Kovtonogova, I. V.
Bobrovskaya, O. V.
Vakhrin, M. I.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2014, 84 (02) : 264 - 267
[30] Reactions of 5-Aryl-4-acyl-3-hydroxy-1-cyanomethyl-3-pyrrolin-2-ones with Aromatic Amines
V. L. Gein
E. A. Buldakova
M. V. Dmitriev
I. G. Mokrushin
Russian Journal of General Chemistry, 2020, 90 : 39 - 44

← 1 2 3 4 5 →