Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)-5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives

被引：4

作者：

Gein, V. L. ^{[1
]}

Kasimova, N. N. ^{[1
]}

Chashchina, S., V ^{[1
]}

Starkova, A., V ^{[1
]}

Syropyatov, B. Ya ^{[1
]}

机构：

[1] Minist Hlth RF, Perm State Pharmaceut Acad, 2 Polevaya St, Perm 614990, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2019年 / 53卷 / 08期

关键词：

4-acyl-1-(2-aminopropyl)-5-aryl-3-hydroxy-3-pyrrolin-2-ones; pyrrolo[3; 4-c]pyrazole; synthesis; anti-inflammatory activity; analgesic activity; hemostatic effect;

D O I：

10.1007/s11094-019-02066-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1-(2-aminopropyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by three-component reactions of 4-substituted 2,4-dioxobutanoic acid methyl esters with mixtures of an aromatic aldehyde and 1,2-diaminopropane. Products of their reactions with hydrazine, p-phenetidine, and acetic anhydride were obtained. The analgesic, anti-inflammatory, and antimicrobial activities and hemostatic effect of several compounds were studied.

引用

页码：701 / 705

页数：5

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