Synthesis of novel tetrapeptides as potential ACE inhibitors

被引：0
|
作者：
Tandon, R
Singh, MP
Haq, W
Dikshit, M
Patnaik, GK
Dhar, MM
机构：
[1] CENT DRUG RES INST,DIV BIOPOLYMERS,LUCKNOW 226001,UTTAR PRADESH,INDIA
[2] CENT DRUG RES INST,DIV PHARMACOL,LUCKNOW 226001,UTTAR PRADESH,INDIA
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1997年 / 36卷 / 05期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pepsin hydrolysis of wheat gluten yields a tetrapeptide, Leu-Gln-Pro-Arg (1) which exhibits potent ACE inhibitory activity. Analogues (2-7) of this peptide have been synthesized and examined for ACE inhibitory activity in vitro and in vivo. None of the compounds synthesized showed improved in vivo activity. However, compound 6 has been found to be as active as captopril in in vitro assay.
引用
收藏
页码：386 / 390
页数：5
相关论文
共 50 条
  • [21] Synthesis and evaluation of novel potential HCV helicase inhibitors
    Brancale, A
    Vlachakis, D
    Barbera, MC
    Silvestri, R
    Berry, C
    Neyts, J
    [J]. ANTIVIRAL RESEARCH, 2006, 70 (01) : A53 - A54
  • [22] Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors
    Olimpieri, Francesca
    Tambaro, Simone
    Fustero, Santos
    Lazzari, Paolo
    Sanchez-Rosello, Maria
    Pani, Luca
    Volonterio, Alessandro
    Zanda, Matteo
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (16) : 4715 - 4719
  • [23] NOVEL MICROBIAL INHIBITORS OF ACE - ISOLATION AND CHARACTERIZATION
    BAUER, K
    MULLER, H
    SCHEDEL, M
    TRUSCHEIT, E
    SCHNABEL, E
    [J]. INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1995, 46 (3-4): : 205 - 208
  • [24] Novel mechanism of action of ACE and its inhibitors
    Carretero, OA
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2005, 289 (05): : H1796 - H1797
  • [25] SYNTHESIS OF A NOVEL CLASS OF PEPTIDES - DILACTAM-BRIDGED TETRAPEPTIDES
    MANESIS, NJ
    GOODMAN, M
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (24): : 5331 - 5341
  • [26] Synthesis of biphenyl derivatives as ACE and α-amylase inhibitors
    Meti, Gangadhar Yamanappa
    Kamble, Ravindra Ramappa
    Biradar, Dharesh Bhimaraya
    Margankop, Sheetal Babu
    [J]. MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (12) : 5868 - 5877
  • [27] Synthesis of biphenyl derivatives as ACE and α-amylase inhibitors
    Gangadhar Yamanappa Meti
    Ravindra Ramappa Kamble
    Dharesh Bhimaraya Biradar
    Sheetal Babu Margankop
    [J]. Medicinal Chemistry Research, 2013, 22 : 5868 - 5877
  • [28] Potential adverse effects of ACE inhibitors concern GPs
    [J]. Reactions Weekly, 1997, 653 (1) : 3 - 3
  • [29] Synthesis of Novel Ligustrazine Derivatives as Potential Platelet Aggregation Inhibitors
    Xian Chao CHENG
    [J]. Chinese Chemical Letters, 2006, (10) : 1317 - 1320
  • [30] Design and synthesis of novel hydroxypyridinone derivatives as potential tyrosinase inhibitors
    Zhao, De-Yin
    Zhang, Ming-Xia
    Dong, Xiao-Wu
    Hu, Yong-Zhou
    Dai, Xiao-Yan
    Wei, Xiaoyi
    Hider, Robert C.
    Zhang, Jin-Chao
    Zhou, Tao
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (13) : 3103 - 3108
12345