[1] Cardiff Univ, Welsh Sch Pharm, Cardiff CF10 3XF, Wales
[2] Univ Roma La Sapienza, Dipartimento Farmaceut, I-00185 Rome, Italy
[3] Cardiff Univ, Cardiff Sch Biosci, Cardiff CF10 3US, Wales
[4] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium