Synthesis of novel tetrapeptides as potential ACE inhibitors

被引：0
|
作者：
Tandon, R
Singh, MP
Haq, W
Dikshit, M
Patnaik, GK
Dhar, MM
机构：
[1] CENT DRUG RES INST,DIV BIOPOLYMERS,LUCKNOW 226001,UTTAR PRADESH,INDIA
[2] CENT DRUG RES INST,DIV PHARMACOL,LUCKNOW 226001,UTTAR PRADESH,INDIA
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1997年 / 36卷 / 05期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pepsin hydrolysis of wheat gluten yields a tetrapeptide, Leu-Gln-Pro-Arg (1) which exhibits potent ACE inhibitory activity. Analogues (2-7) of this peptide have been synthesized and examined for ACE inhibitory activity in vitro and in vivo. None of the compounds synthesized showed improved in vivo activity. However, compound 6 has been found to be as active as captopril in in vitro assay.
引用
收藏
页码：386 / 390
页数：5
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