Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

被引：0
|
作者：
Akiko Doi
In-Hyun Park
Bo Wen
Peter Murakami
Martin J Aryee
Rafael Irizarry
Brian Herb
Christine Ladd-Acosta
Junsung Rho
Sabine Loewer
Justine Miller
Thorsten Schlaeger
George Q Daley
Andrew P Feinberg
机构：
[1] Johns Hopkins University School of Medicine,Center for Epigenetics and Department of Medicine
[2] Children's Hospital Boston and Howard Hughes Medical Institute,Division of Pediatric Hematology/Oncology
[3] Johns Hopkins Bloomberg School of Public Health,Department of Biostatistics
[4] Sidney Kimmel Comprehensive Cancer Center,undefined
[5] Johns Hopkins University,undefined
来源：
Nature Genetics | 2009年 / 41卷
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学科分类号：
摘要：
Andrew Feinberg and colleagues show that differential methylation of CpG island shores distinguish human induced pluripotent stem cells from the fibroblasts from which they were derived. These differentially methylated regions of the genome can also distinguish normal colon tissue from colorectal cancer.
引用
收藏
页码：1350 / 1353
页数：3
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