Production of erythroid cells from human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPS)

被引：14
|
作者：
Anstee, D. J. [1 ]
机构：
[1] NHSBT, Bristol Inst Transfus Sci, Bristol BS34 7QG, Avon, England
来源：
TRANSFUSION CLINIQUE ET BIOLOGIQUE | 2010年 / 17卷 / 03期
基金：
英国惠康基金;
关键词：
Erythrocytes; hESC; hiPS; Erythropoiesis; RED-BLOOD-CELLS; HEMATOPOIETIC-STEM; CARBOHYDRATE MOIETY; IN-VITRO; GENERATION; LACTOSAMINOGLYCAN; ENUCLEATION;
D O I：
10.1016/j.tracli.2010.05.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Erythroid progenitors can he generated ex vivo from human embryonic stem cells (hESC) or human Induced pluripotent stem cells (hiPS) Development of laboratory scale culture conditions capable of generating mature functional erythrocytes from human embryonic stem cells or human induced pluripotent stem cells would open the possibility for manufacture of therapeutic quantities of red cells and thereby new clinical transfusion products Current attempts to produce erythrocytes from human embryonic stem cells reveal the need for greater understanding of the process whereby primitive erythropoiesis switches to definitive fetal and adult erythropoiesis and the factors driving erythrocyte maturation Studies with human embryonic stem cells have already yielded encouraging results but functional mature biconcave erythrocytes have yet to he generated from these cells (C) 2010 Published by Elsevier Masson SAS
引用
收藏
页码：104 / 109
页数：6
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