Palladium-catalyzed C-H formylation of electron-rich heteroarenes through radical dichloromethylation

被引：8
|
作者：
Bao, Yan
Wang, Jian-Yong
Zhang, Ya-Xuan
Li, Yan
Wang, Xi-Sheng [1 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, 96 Jinzhai Rd, Hefei 230026, Anhui, Peoples R China
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 32期
基金：
美国国家科学基金会;
关键词：
Palladium-catalyzed; Formylation; Radical; Heteroarenes; BOND FUNCTIONALIZATION; NATURAL-PRODUCTS; COMPLEX; OXIDATION; INDOLES; MILD;
D O I：
10.1016/j.tetlet.2018.07.013
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel palladium-catalyzed C-H formylation of electron-rich N-, O-, and S-containing heteroarenes has been developed. The key to success is that the commercially available BrCHCl2 was used as a stoichiometric carbonyl source. Mechanistic investigations indicated that different from the known Reimer-Tiemann reaction, this net C-H formylation proceeded through an electrophilc radical-type path. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3147 / 3150
页数：4
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