In this paper, we discuss model checking with residual diagnostic plots for g-estimation of optimal dynamic treatment regimes. The g-estimation method requires three different model specifications at each treatment interval under consideration: (1) the blip model; (2) the expected counterfactual model; and (3) the propensity model. Of these, the expected counterfactual model is especially difficult to specify correctly in practice and so far there has been little guidance as to how to check for model misspecification. Residual plots are a useful and standard tool for model diagnostics in the classical regression setting; we have adapted this approach for g-estimation. We demonstrate the usefulness of our approach in a simulation study, and apply it to real data in the context of estimating the optimal time to stop breastfeeding.
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Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI 53792 USAUniv Wisconsin, Dept Biostat & Med Informat, Madison, WI 53792 USA
Zhao, Ying-Qi
Zeng, Donglin
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Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USAUniv Wisconsin, Dept Biostat & Med Informat, Madison, WI 53792 USA
Zeng, Donglin
Laber, Eric B.
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N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USAUniv Wisconsin, Dept Biostat & Med Informat, Madison, WI 53792 USA
Laber, Eric B.
Kosorok, Michael R.
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Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Stat & Operat Res, Chapel Hill, NC 27599 USAUniv Wisconsin, Dept Biostat & Med Informat, Madison, WI 53792 USA
机构:
Univ North Carolina Chapel Hill, Dept Biostat, 135 Dauer Dr 3101 McGavran Greenberg Hall,CB 7420, Chapel Hill, NC 27599 USAUniv North Carolina Chapel Hill, Dept Biostat, 135 Dauer Dr 3101 McGavran Greenberg Hall,CB 7420, Chapel Hill, NC 27599 USA
Batorsky, Anna
Anstrom, Kevin J.
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Univ North Carolina Chapel Hill, Dept Biostat, 135 Dauer Dr 3101 McGavran Greenberg Hall,CB 7420, Chapel Hill, NC 27599 USAUniv North Carolina Chapel Hill, Dept Biostat, 135 Dauer Dr 3101 McGavran Greenberg Hall,CB 7420, Chapel Hill, NC 27599 USA
Anstrom, Kevin J.
Zeng, Donglin
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Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USAUniv North Carolina Chapel Hill, Dept Biostat, 135 Dauer Dr 3101 McGavran Greenberg Hall,CB 7420, Chapel Hill, NC 27599 USA
机构:
Univ Sheffield, Sch Hlth & Related Res, 30 Regent St, Sheffield S1 4DA, S Yorkshire, EnglandUniv Sheffield, Sch Hlth & Related Res, 30 Regent St, Sheffield S1 4DA, S Yorkshire, England
Latimer, N. R.
White, I. R.
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UCL, MRC Clin Trials Unit, London, EnglandUniv Sheffield, Sch Hlth & Related Res, 30 Regent St, Sheffield S1 4DA, S Yorkshire, England
White, I. R.
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Tilling, K.
Siebert, U.
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UMIT Univ Hlth Sci Med Informat & Technol, Dept Publ Hlth Hlth Serv Res & Hlth Technol Asses, Hall In Tirol, Austria
ONCOTYROL Ctr Personalized Canc Med, Innsbruck, Austria
Harvard Med Sch, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA
Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USAUniv Sheffield, Sch Hlth & Related Res, 30 Regent St, Sheffield S1 4DA, S Yorkshire, England