[1] Univ Catolica Portuguesa, Inst Ciencias Saude, Ctr Invest Interdisciplinar Saude, Rua Diogo Botelho 1327, P-4169005 Porto, Portugal
[2] Hosp Forcas Armadas Polo Porto, Ave Boavista, P-4050113 Porto, Portugal
[3] IQVIA, Patient Ctr Solut, San Francisco, CA 94105 USA
[4] IQVIA, Patient Ctr Endpoints, Patient Ctr Solut, Madrid 28007, Spain
[5] Univ Aveiro, iBiMED Inst Biomed, Dept Med Sci, Campus Univ Santiago,Agra Crasto Edificio 30, P-3810193 Aveiro, Portugal