Alternative splicing of the human PTEN/MMAC1/TEP1 gene

被引：31

作者：

Sharrard, RM ^{[1
]}

Maitland, NJ ^{[1
]}

机构：

[1] Univ York, Dept Biol, YCR Canc Res Unit, York YO10 5DD, N Yorkshire, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2000年 / 1494卷 / 03期

关键词：

PTEN/MMAC1/TEP1; alternative splicing; reverse transcriptase polymerase chain reaction; phosphatase;

D O I：

10.1016/S0167-4781(00)00210-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human tumour suppressor gene PTEN/MMAC1/TEP1 encodes a lipid and protein phosphatase. Using RT-PCR, alternatively spliced forms of PTEN mRNA, encoding full-length PTEN and two forms of the protein truncated at the C-terminal end, were detected in normal human tissue. Cultured tumour and non-tumour cell lines show similar splicing patterns. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：282 / 285

页数：4

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