抑癌基因PTEN/MMAC1/TEP1与肺癌

[1] Inhibition of cell migration,spreading, and focal adhesions by tumor suppressor PTEN. Tamura M,Gu J,Matsumoto K,et al. Science . 1998

[2] Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis. Hosoya Y,Gemma A,Seike M,et al. Lung Cancer . 1999

[3] Methylation profiling of twenty promoterCpG islands of genes which may contribute to hepatocellular carcinogenesis. Yu J,Ni M,Xu J,et al. BMC Cancer . 2002

[4] Silencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancer. Frisk T,Foukakis T,Dwight T,et al. Genes Chromosomes and Cancer . 2002

[5] Identification of a candidate tumour suppressor gene,MMAC1,at chromosome10q23.3that is mutated in multiple advanced cancers. Steck PA,Pershouse MA,Jasser SA,et al. Nature Genetics . 1997

[6] Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Kandel ES,Skeen J,Majewski N,et al. Molecular and Cellular Biology . 2002

[7] PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells. Stewart AL,Mhashilkar AM,Yang XH,et al. Molecular Medicine . 2002

[8] Alteration of PTEN expression in endometrial carcinoma is associated with down-regulation of cyclindependent kinase inhibitor, p27. An HJ,Shim JY,Kim SJ. Histopathology . 2002

[9] Adenovirusmediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes. Cheney IW,Neuteboom ST,Vaillancourt MT,et al. Cancer Research . 1999

[10] MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer. Koul D,Shen R,Garyali A,et al. International Journal of Oncology . 2002

[1] Inhibition of cell migration,spreading, and focal adhesions by tumor suppressor PTEN. Tamura M,Gu J,Matsumoto K,et al. Science . 1998

[2] Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis. Hosoya Y,Gemma A,Seike M,et al. Lung Cancer . 1999

[3] Methylation profiling of twenty promoterCpG islands of genes which may contribute to hepatocellular carcinogenesis. Yu J,Ni M,Xu J,et al. BMC Cancer . 2002

[4] Silencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancer. Frisk T,Foukakis T,Dwight T,et al. Genes Chromosomes and Cancer . 2002

[5] Identification of a candidate tumour suppressor gene,MMAC1,at chromosome10q23.3that is mutated in multiple advanced cancers. Steck PA,Pershouse MA,Jasser SA,et al. Nature Genetics . 1997

[6] Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Kandel ES,Skeen J,Majewski N,et al. Molecular and Cellular Biology . 2002

[7] PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells. Stewart AL,Mhashilkar AM,Yang XH,et al. Molecular Medicine . 2002

[8] Alteration of PTEN expression in endometrial carcinoma is associated with down-regulation of cyclindependent kinase inhibitor, p27. An HJ,Shim JY,Kim SJ. Histopathology . 2002

[9] Adenovirusmediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes. Cheney IW,Neuteboom ST,Vaillancourt MT,et al. Cancer Research . 1999

[10] MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer. Koul D,Shen R,Garyali A,et al. International Journal of Oncology . 2002