Alternative splicing of the human PTEN/MMAC1/TEP1 gene

被引：31
|
作者：
Sharrard, RM [1 ]
Maitland, NJ [1 ]
机构：
[1] Univ York, Dept Biol, YCR Canc Res Unit, York YO10 5DD, N Yorkshire, England
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2000年 / 1494卷 / 03期
关键词：
PTEN/MMAC1/TEP1; alternative splicing; reverse transcriptase polymerase chain reaction; phosphatase;
D O I：
10.1016/S0167-4781(00)00210-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The human tumour suppressor gene PTEN/MMAC1/TEP1 encodes a lipid and protein phosphatase. Using RT-PCR, alternatively spliced forms of PTEN mRNA, encoding full-length PTEN and two forms of the protein truncated at the C-terminal end, were detected in normal human tissue. Cultured tumour and non-tumour cell lines show similar splicing patterns. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：282 / 285
页数：4
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