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Alternative splicing of the human PTEN/MMAC1/TEP1 gene
被引:31
|作者:
Sharrard, RM
[1
]
Maitland, NJ
[1
]
机构:
[1] Univ York, Dept Biol, YCR Canc Res Unit, York YO10 5DD, N Yorkshire, England
来源:
关键词:
PTEN/MMAC1/TEP1;
alternative splicing;
reverse transcriptase polymerase chain reaction;
phosphatase;
D O I:
10.1016/S0167-4781(00)00210-4
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The human tumour suppressor gene PTEN/MMAC1/TEP1 encodes a lipid and protein phosphatase. Using RT-PCR, alternatively spliced forms of PTEN mRNA, encoding full-length PTEN and two forms of the protein truncated at the C-terminal end, were detected in normal human tissue. Cultured tumour and non-tumour cell lines show similar splicing patterns. (C) 2000 Elsevier Science B.V. All rights reserved.
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页码:282 / 285
页数:4
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