Synthesis and Anticancer Activities of Some Thiazole Derivatives

被引：24
|
作者：
Kayagil, Ismail [1 ]
Demirayak, Seref [1 ]
机构：
[1] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2009年 / 184卷 / 09期
关键词：
Anticancer activity; poly-thiazole; thiazolone; 2,4-DISUBSTITUTED THIAZOLES; ANALOGS; AGENTS;
D O I：
10.1080/10426500802446181
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.
引用
收藏
页码：2197 / 2207
页数：11
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