Synthesis and Anticancer Activities of Some Thiazole Derivatives

被引：24
|
作者：
Kayagil, Ismail [1 ]
Demirayak, Seref [1 ]
机构：
[1] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2009年 / 184卷 / 09期
关键词：
Anticancer activity; poly-thiazole; thiazolone; 2,4-DISUBSTITUTED THIAZOLES; ANALOGS; AGENTS;
D O I：
10.1080/10426500802446181
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.
引用
收藏
页码：2197 / 2207
页数：11
相关论文
共 50 条
  • [21] Green Synthesis and Anti-microbial Activities of Some Thiazole-imino Derivatives
    Singh, Satbir
    Raj, Seema
    Sharma, Sunil Kumar
    Sucheta
    Yadav, Vijay Kumar
    ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY, 2023, 15 (02): : 76 - 81
  • [22] Synthesis and evaluation of novel ferrocenyl thiazole derivatives as anticancer agents
    Shao, L
    Zhou, X
    Hu, Y
    Jin, Z
    Liu, JB
    Fang, JX
    SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY, 2006, 36 (04) : 325 - 330
  • [23] Synthesis, anticancer activity and mechanism of action of new thiazole derivatives
    de Santana, Temistocles Italo
    Barbosa, Miria de Oliveira
    Teixeira de Moraes Gomes, Paulo Andre
    Nascimento da Cruz, Anne Cecilia
    da Silva, Teresinha Gonsalves
    Lima Leite, Ana Cristina
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 144 : 874 - 886
  • [24] Design, Synthesis, and Anticancer Activity of New Derivatives of Thiazole and Imidazole
    El-Deen, I. M.
    Elsayed, E. H.
    El-Ahwany, M.
    Abd El-Azez, M. S.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2020, 90 (12) : 2350 - 2355
  • [25] Design, Synthesis, and Anticancer Activity of New Derivatives of Thiazole and Imidazole
    I. M. El-Deen
    E. H. Elsayed
    M. El-Ahwany
    M. S. Abd El-Azez
    Russian Journal of General Chemistry, 2020, 90 : 2350 - 2355
  • [26] Synthesis and Antifungal Activity of Some Thiazole Derivatives
    Song, Ya-Li
    Liu, Xiao-Ming
    Yang, Ning
    Yang, Geng-Liang
    ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (04) : 1849 - 1852
  • [27] SYNTHESIS AND FLUORESCENCE OF SOME THIAZOLE AND BENZOTHIAZOLE DERIVATIVES
    BELGODERE, E
    BOSSIO, R
    CHIMICHI, S
    PARRINI, V
    PEPINO, R
    DYES AND PIGMENTS, 1983, 4 (01) : 59 - 71
  • [28] Recent Literature on the Synthesis of Thiazole Derivatives and their Biological Activities
    Farghaly, Thoraya A.
    Alfaifi, Ghaidaa H.
    Gomha, Sobhi M.
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2024, 24 (02) : 196 - 251
  • [29] Synthesis of some imidazolyl-thioacetyl-pyrazolinone derivatives and their antinociceptive and anticancer activities
    Demirayak, Seref
    Kayagil, Ismail
    Yurttas, Leyla
    Aslan, Rana
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2010, 25 (01) : 74 - 79
  • [30] Synthesis and antimicrobial activities of some novel thiazole compounds
    Turan-Zitouni, Gulhan
    Cavusoglu, Betul Kaya
    Saglik, Begum Nurpelin
    Cevik, Ulviye Acar
    TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, 2018, 43 (03): : 220 - 227
12345