Synthesis and Anticancer Activities of Some Thiazole Derivatives

被引：24
|
作者：
Kayagil, Ismail [1 ]
Demirayak, Seref [1 ]
机构：
[1] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2009年 / 184卷 / 09期
关键词：
Anticancer activity; poly-thiazole; thiazolone; 2,4-DISUBSTITUTED THIAZOLES; ANALOGS; AGENTS;
D O I：
10.1080/10426500802446181
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.
引用
收藏
页码：2197 / 2207
页数：11
相关论文
共 50 条
  • [41] Synthesis of some triheterocyclic thiazole derivatives of biological interest
    Kalluraya, B
    Gunaga, P
    Ramana, MV
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 1999, 8 (03) : 241 - 242
  • [42] Synthesis of new thiazole derivatives and evaluation of their antimicrobial and cytotoxic activities
    Dawbaa, Sam
    Evren, Asaf Evrim
    Canturk, Zerrin
    Yurttas, Leyla
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2021, 196 (12) : 1093 - 1102
  • [43] Synthesis of Some Benzothiazole Based Piperazine-Dithiocarbamate Derivatives and Evaluation of Their Anticancer Activities
    Turan-Zitouni, Gulhan
    Ozkay, Yusuf
    Ozdemir, Ahmet
    Kaplancikli, Zafer Asim
    Altintop, Mehlika Dilek
    LETTERS IN DRUG DESIGN & DISCOVERY, 2011, 8 (09) : 830 - 837
  • [44] In vitro anticancer activities of some organoplatinum (IV) derivatives
    Howard, William A.
    MOLECULAR CANCER THERAPEUTICS, 2024, 23 (12)
  • [45] Synthesis and Anticancer Evaluation of New Thiazole and Thiadiazole Derivatives Bearing Acetanilide Moiety
    Ali El-Rayyes
    Ahbarah M. Soliman
    Ali Saeed
    Russian Journal of General Chemistry, 2022, 92 : 2132 - 2144
  • [46] Synthesis, in vitro antioxidant, anticancer activity and molecular docking of new thiazole derivatives
    Hussein, Ahmed M.
    Al Bahir, Areej
    Zaki, Yasser H.
    Ahmed, Osama M.
    Eweas, Ahmad F.
    Elroby, Shaaban A.
    Mohamed, Mahmoud A.
    RESULTS IN CHEMISTRY, 2024, 7
  • [47] Design, synthesis and anticancer evaluation of isoxazole fused thiazole-oxazole derivatives
    Lingala, Arun Kumar
    Mothe, Thirupathi
    Murahari, Kiran Kumar
    Desireddi, Janardana Reddi
    Maiti, Bhimcharan
    Manchal, Ravinder
    CHEMICAL DATA COLLECTIONS, 2022, 41
  • [48] Synthesis and Anticancer Evaluation of New Thiazole and Thiadiazole Derivatives Bearing Acetanilide Moiety
    El-Rayyes, Ali
    Abdel-Latif, Ehab
    Soliman, Ahbarah M.
    Saeed, Ali
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2022, 92 (10) : 2132 - 2144
  • [49] Synthesis, Anticancer and Antioxidant Activity of Novel Carbazole-based Thiazole Derivatives
    Minh An Tran Nguyen
    Mungara, Anil Kumar
    Kim, Jung-Ae
    Lee, Kap Duk
    Park, Soonheum
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2015, 190 (02) : 191 - 199
  • [50] Synthesis and in vitro anticancer potential of new thiazole-containing derivatives of rhodanine
    Los, Oleksandr V.
    Sinenko, Vitalii O.
    Kobzar, Oleksandr L.
    Zhirnov, Victor V.
    Vovk, Andriy I.
    Brovarets, Volodymyr S.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2023, 59 (6-7) : 484 - 493
12345