Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives

被引：25
|
作者：
Li, Yang [1 ,2 ]
Feng, Ling [1 ]
Song, Zhi-Fang [1 ]
Li, Hai-Bei [1 ]
Huai, Qi-Yong [1 ]
机构：
[1] Shandong Univ, Marine Coll, Weihai 264209, Peoples R China
[2] Taishan Med Univ, Affiliated Liaocheng Hosp, Liaocheng Peoples Hosp, Zhong Yuan Acad Biol Med, Liaocheng 252000, Peoples R China
来源：
MOLECULES | 2016年 / 21卷 / 02期
关键词：
glycyrrhetinic acid (GA); derivatives; anticancer; MCF-7; MDA-MB-231; FERULIC ACID; GLYCYRRHIZIC ACID; IN-VITRO; TRITERPENOIDS; CELLS;
D O I：
10.3390/molecules21020199
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluation results revealed that, in comparison with GA, compound 42 shows the most promising anticancer activity (IC50 1.88 +/- 0.20 and 1.37 +/- 0.18 M for MCF-7 and MDA-MB-231, respectively) and merits further exploration as a new anticancer agent.
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页数：20
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