Synthesis, phytotoxic, cytotoxic, acetylcholinesterase and butrylcholinesterase activities of N,N′-diaryl unsymmetrically substituted thioureas

被引：17
|
作者：
Begum, Saeedan [1 ]
Choudhary, M. Iqbal [1 ]
Khan, Khalid M. [1 ]
机构：
[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 5270, Pakistan
来源：
NATURAL PRODUCT RESEARCH | 2009年 / 23卷 / 18期
关键词：
N; N '-diaryl unsymmetrically substituted thiourea derivatives; phytotoxicity; cytotoxicity; acetylcholinesterase activity; butrylcholinesterase activity; CYTOKININ ACTIVITY; DERIVATIVES; POTENT; INHIBITORS; DESIGN;
D O I：
10.1080/14786410802223778
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Fourteen N,N'-diaryl unsymmetrically substituted thioureas were synthesised and their cytotoxic ( in vitro), phytotoxic ( in vitro), acetylcholinesterase and butrylcholinesterase activities were determined. Thiourea 16 exhibited high, and 1 and 3 showed significant phytotoxic activity. Thioureas 1, 3, 4, 6 and 10 showed significant activity and 2, 6 and 7 indicated moderate cytotoxic activities. Compound 12 exhibited butrylcholinesterase activity higher than a standard reference.
引用
收藏
页码：1719 / 1730
页数：12
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