Synthesis, phytotoxic, cytotoxic, acetylcholinesterase and butrylcholinesterase activities of N,N′-diaryl unsymmetrically substituted thioureas

被引：17
|
作者：
Begum, Saeedan [1 ]
Choudhary, M. Iqbal [1 ]
Khan, Khalid M. [1 ]
机构：
[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 5270, Pakistan
来源：
NATURAL PRODUCT RESEARCH | 2009年 / 23卷 / 18期
关键词：
N; N '-diaryl unsymmetrically substituted thiourea derivatives; phytotoxicity; cytotoxicity; acetylcholinesterase activity; butrylcholinesterase activity; CYTOKININ ACTIVITY; DERIVATIVES; POTENT; INHIBITORS; DESIGN;
D O I：
10.1080/14786410802223778
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Fourteen N,N'-diaryl unsymmetrically substituted thioureas were synthesised and their cytotoxic ( in vitro), phytotoxic ( in vitro), acetylcholinesterase and butrylcholinesterase activities were determined. Thiourea 16 exhibited high, and 1 and 3 showed significant phytotoxic activity. Thioureas 1, 3, 4, 6 and 10 showed significant activity and 2, 6 and 7 indicated moderate cytotoxic activities. Compound 12 exhibited butrylcholinesterase activity higher than a standard reference.
引用
收藏
页码：1719 / 1730
页数：12
相关论文
共 50 条
  • [31] On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted-N′-acyl thioureas
    Plutin, Ana M.
    Mocelo, Raul
    Alvarez, Anislay
    Ramos, Raul
    Castellano, Eduardo E.
    Cominetti, Marcia R.
    Graminha, Angelica E.
    Ferreira, Antonio G.
    Batista, Alzir A.
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2014, 134 : 76 - 82
  • [32] Unsymmetrically substituted N-heterocyclic phosphenium ions
    Schmid, Dirk
    Bubrin, Denis
    Foerster, Daniela
    Nieger, Martin
    Roeben, Eric
    Strobel, Sabine
    Gudat, Dietrich
    COMPTES RENDUS CHIMIE, 2010, 13 (8-9) : 998 - 1005
  • [33] Synthesis, Structure Analysis and Cytotoxicity Studies of Novel Unsymmetrically N,N′-Substituted Ureas from Dehydroabietic Acid
    Rao, Xiaoping
    Song, Zhanqian
    He, Ling
    Jia, Weihong
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (11) : 1575 - 1578
  • [34] Unsymmetrically substituted organotin (IV) N-alkyl, N-hydroxyethyl dithiocarbamates: Synthesis and spectral aspects
    Srivastava, S. K.
    Pandey, H.
    Sharma, R.
    INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 2007, 46 (07): : 1105 - 1108
  • [35] Access to Unsymmetrically Substituted Diaryl Gold N-Acyclic Carbene (NAC) and N-Heterocyclic Carbene (NHC) Complexes via the Isonitrile Route
    Vethacke, Vanessa
    Claus, Vanessa
    Dietl, Martin C.
    Ehjeij, Daniel
    Meister, Arne
    Huber, Jonas F.
    Darian, Leon K. Paschai
    Rudolph, Matthias
    Rominger, Frank
    Hashmi, A. Stephen K.
    ADVANCED SYNTHESIS & CATALYSIS, 2022, 364 (03) : 536 - 554
  • [36] UNSYMMETRICALLY SUBSTITUTED N- AND B-METHYLBORAZINES
    BEACHLEY, OT
    INORGANIC CHEMISTRY, 1969, 8 (04) : 981 - &
  • [37] CONFIGURATIONS IN UNSYMMETRICALLY N-METHYL-N-SUBSTITUTED 2-PHENYLACETAMIDES
    PETROVIC, S
    VAJS, VE
    NIKOLIC, AD
    STOJANOVIC, ND
    JOURNAL OF MOLECULAR STRUCTURE, 1986, 142 : 451 - 453
  • [38] SYNTHESIS OF N,N-DIARYL-N1-ACYLHYDRAZINES
    ZHESTKOV, VP
    VORONIN, VG
    PORTNOV, YN
    ZHURNAL ORGANICHESKOI KHIMII, 1986, 22 (07): : 1560 - 1561
  • [39] The synthesis of unsymmetrically N-substituted chiral 1,4,7-triazacyclononanes
    Scheuermann, JEW
    Sibbons, KF
    Benoit, DM
    Motevalli, M
    Watkinson, M
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (18) : 2664 - 2670
  • [40] N,N′'-Substituted thioureas and their metal complexes: syntheses, structures and electronic properties
    Al-Riyahee, Ali A. A.
    Horton, Peter N.
    Coles, Simon J.
    Berry, Colin
    Horrocks, Paul D.
    Pope, Simon J. A.
    Amoroso, Angelo J.
    DALTON TRANSACTIONS, 2022, 51 (09) : 3531 - 3545
12345