A highly efficient Suzuki cross-coupling reaction between benzylic halides and aryl boronic acids using palladium chloride as catalyst in acetone:water (3:1) as the solvent system has been developed. High yields of products, mild reaction conditions and short reaction times in the absence of ligand are important features of this method. (C) 2004 Elsevier Ltd. All rights reserved.
机构:
Fac Sci & Tech St Jerome, CNRS, UMR 6180, Synth Organ Lab, F-13397 Marseille 20, FranceFac Sci & Tech St Jerome, CNRS, UMR 6180, Synth Organ Lab, F-13397 Marseille 20, France
Kondolff, I
Doucet, H
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Fac Sci & Tech St Jerome, CNRS, UMR 6180, Synth Organ Lab, F-13397 Marseille 20, FranceFac Sci & Tech St Jerome, CNRS, UMR 6180, Synth Organ Lab, F-13397 Marseille 20, France
Doucet, H
Santelli, M
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Fac Sci & Tech St Jerome, CNRS, UMR 6180, Synth Organ Lab, F-13397 Marseille 20, FranceFac Sci & Tech St Jerome, CNRS, UMR 6180, Synth Organ Lab, F-13397 Marseille 20, France