Violapyrones A-G, α-Pyrone Derivatives from Streptomyces violascens Isolated from Hylobates hoolock Feces

被引：51

作者：

Zhang, Jiaoyue ^{[1
]}

Jiang, Yi ^{[2
]}

Cao, Yanru ^{[2
]}

Liu, Jiang ^{[3
]}

Zheng, Dan ^{[1
]}

Chen, Xiu ^{[2
]}

Han, Li ^{[3
]}

Jiang, Chenglin ^{[2
,3
]}

Huang, Xueshi ^{[1
]}

机构：

[1] China Med Univ, Lab Metab Dis Res & Drug Dev, Shenyang 110001, Peoples R China

[2] Yunnan Univ, Yunnan Inst Microbiol, Kunming 650091, Peoples R China

[3] Northeastern Univ, Coll Life & Hlth Sci, Inst Microbial Pharmaceut, Shenyang 110819, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 11期

基金：

中国国家自然科学基金;

关键词：

ANTIBIOTICS; METABOLITES; GUT;

D O I：

10.1021/np4003417

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new 3,4,6-trisubstituted alpha-pyrone derivatives, violapyrones A-G (1-7), were isolated from Streptomyces violascens obtained from Hylobates hoolock feces. Their structures were elucidated on the basis of detailed spectroscopic analysis. The antimicrobial activities of 1-7 were evaluated against Gram-positive and Gram-negative bacteria and against fungi. Compounds 1-3 showed moderate antibacterial activities against Bacillus subtilis and Staphylococcus aureus with MIC values of 4-32 mu g/mL.

引用

页码：2126 / 2130

页数：5

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