Violapyrones A-G, α-Pyrone Derivatives from Streptomyces violascens Isolated from Hylobates hoolock Feces

被引：51
|
作者：
Zhang, Jiaoyue [1 ]
Jiang, Yi [2 ]
Cao, Yanru [2 ]
Liu, Jiang [3 ]
Zheng, Dan [1 ]
Chen, Xiu [2 ]
Han, Li [3 ]
Jiang, Chenglin [2 ,3 ]
Huang, Xueshi [1 ]
机构：
[1] China Med Univ, Lab Metab Dis Res & Drug Dev, Shenyang 110001, Peoples R China
[2] Yunnan Univ, Yunnan Inst Microbiol, Kunming 650091, Peoples R China
[3] Northeastern Univ, Coll Life & Hlth Sci, Inst Microbial Pharmaceut, Shenyang 110819, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 11期
基金：
中国国家自然科学基金;
关键词：
ANTIBIOTICS; METABOLITES; GUT;
D O I：
10.1021/np4003417
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Seven new 3,4,6-trisubstituted alpha-pyrone derivatives, violapyrones A-G (1-7), were isolated from Streptomyces violascens obtained from Hylobates hoolock feces. Their structures were elucidated on the basis of detailed spectroscopic analysis. The antimicrobial activities of 1-7 were evaluated against Gram-positive and Gram-negative bacteria and against fungi. Compounds 1-3 showed moderate antibacterial activities against Bacillus subtilis and Staphylococcus aureus with MIC values of 4-32 mu g/mL.
引用
收藏
页码：2126 / 2130
页数：5
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