Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77

被引：28

作者：

Ren, Jinwei ^{[2
]}

Liu, Dong ^{[2
]}

Tian, Li ^{[3
]}

Wei, Yangye ^{[1
]}

Proksch, Peter ^{[4
]}

Zeng, Jinzhang ^{[1
]}

Lin, Wenhan ^{[2
]}

机构：

[1] Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[3] Qingdao Univ Sci & Technol, Dept Biol, Qingdao 266042, Peoples R China

[4] Univ Dusseldorf, Inst Pharmaceut Biotechnol, D-40225 Dusseldorf, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 01期

关键词：

Streptomyces venezuelae; Phenoxazine-based alkaloids; Venezuelines; Structural elucidation; Cytotoxic activity; Nur77; expression; ABSOLUTE-CONFIGURATION; CELL-LINES;

D O I：

10.1016/j.bmcl.2012.10.096

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new phenoxazine-based alkaloids venezuelines A-E (1-5) and two new aminophenols venezuelines F-G (6-7), as well as three known analogues exfoliazone, chandrananimycin D and carboxyexfoliazone were isolated from the fermentation broth of the marine-derived bacterium Streptomyces venezuelae. The structures of new compounds were determined on the basis of extensive spectroscopic analysis. The cytotoxic activity of these compounds against a panel of tumor cell lines were tested, while the regulation of gene target Nur77 of 2 and exfoliazone (8) were evaluated. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：301 / 304

页数：4