Versatile Synthesis of Fused Tricyclic 1,2,4-Triazole Derivatives

被引：5

作者：

Ellis, David ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Discovery Chem, Sandwich CT13 9NJ, Kent, England

来源：

SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 07期

关键词：

Fused tricyclic ring system; intramolecular reduction cyclization; Suzuki reaction; 1,2,4-triazole; vicarious nucleophilic substitution;

D O I：

10.1080/00397911003707170

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[image omitted] The synthesis of a small series of fused tricyclic 1,2,4-triazoles is described. The key reaction is an intramolecular two-stage, one-pot reduction/cyclization sequence of a nitropyridine/oxadiazole substrate to give the key tricyclic triazole. Further standard transformations convert this template into a series of final target compounds.

引用

页码：963 / 975

页数：13

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