Versatile Synthesis of Fused Tricyclic 1,2,4-Triazole Derivatives

被引：5
|
作者：
Ellis, David [1 ]
机构：
[1] Pfizer Global Res & Dev, Discovery Chem, Sandwich CT13 9NJ, Kent, England
来源：
SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 07期
关键词：
Fused tricyclic ring system; intramolecular reduction cyclization; Suzuki reaction; 1,2,4-triazole; vicarious nucleophilic substitution;
D O I：
10.1080/00397911003707170
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[image omitted] The synthesis of a small series of fused tricyclic 1,2,4-triazoles is described. The key reaction is an intramolecular two-stage, one-pot reduction/cyclization sequence of a nitropyridine/oxadiazole substrate to give the key tricyclic triazole. Further standard transformations convert this template into a series of final target compounds.
引用
收藏
页码：963 / 975
页数：13
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