SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1,2,4-TRIAZOLE DERIVATIVES

被引：0
|
作者：
TALAWAR, MB [1 ]
LADDI, UV [1 ]
SOMANNAVAR, YS [1 ]
BENNUR, RS [1 ]
BENNUR, SC [1 ]
机构：
[1] KARNATAK UNIV,POSTGRAD DEPT STUDIES CHEM,DHARWAD 580003,KARNATAKA,INDIA
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 4卷 / 04期
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D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reactions of 3-(4-substituted anilinoethyl)-4-amino-5-mercapto-4(H)-1,2,4-triazoles with various aliphatic/aromatic acids, cyanogen bromide, carbon disulphide, hydrazine hydrate, dimedone and monochloroacetic acid are described. Antimicrobial screening of all the synthesised compounds against bacteria Bacillus cirroflagellosus, Escherichia coli and fungi Candida albicans, Aspergillus niger have been carried out. Some of the compounds have shown most significant antifungal activity (Relative inhibition, RI = 60-93%), against both the fungal strains. However most of the compounds have shown moderate antibacterial activity (RI = 30-60%). An attempt is made to study the structure activity relationship (SAR).
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页码：297 / 300
页数：4
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