Intermolecular coupling of 2-iodoanilides with benzoxazoles: synthesis of N-(2-Benzoxazol-2-ylphenyl)benzamides via C-H activation

被引：9
|
作者：
Sasmal, Swarnendu [1 ]
Sen, Indira [1 ]
Hall, Roger G. [2 ]
Pal, Sitaram [1 ]
机构：
[1] Syngenta Biosci Pvt Ltd, Santa Monica Works, Ilhas 403110, Goa, India
[2] Muenchwilen AG, Syngenta Crop Protect, CH-4332 Stein, Switzerland
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 11期
关键词：
Benzoxazole; C-H activation; Intermolecular coupling; o-lodoanilides; INTRAMOLECULAR O-ARYLATION; CATALYZED DIRECT ARYLATION; ONE-POT SYNTHESIS; HETEROAROMATIC-COMPOUNDS; COCATALYTIC SYSTEM; CARBOXYLIC-ACIDS; BOND FORMATION; IN-VIVO; WATER; FERMENTATION;
D O I：
10.1016/j.tetlet.2015.01.150
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Using CuI/xantphos/Pd(OAc)(2) catalytic system, the intermolecular C-C cross coupling between benzoxazoles and ortho-haloanilides has been developed in moderate to good yields. The procedure tolerates a series of functional groups on benzoxazole, such as ester, chloro, methyl, and methoxy groups. This divergent approach provides access to various N-(2-Benzoxazol-2-ylphenyl)amides. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1374 / 1377
页数：4
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