Synthesis of 2-Substituted Quinolines via Rhodium(III)-Catalyzed C-H Activation of Imidamides and Coupling with Cyclopropanols

被引：57
|
作者：
Zhou, Xukai [1 ,2 ]
Qi, Zisong [1 ]
Yu, Songjie [1 ]
Kong, Lingheng [1 ,2 ]
Li, Yang [3 ]
Tian, Wan-Fa [3 ]
Li, Xingwei [1 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Ctr Organ Chem, Xian 710054, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 10期
关键词：
C-H activation; C-N bond formation; cyclopropanols; imidamides; 2-substituted quinolines; N BOND FORMATION; ONE-POT SYNTHESIS; INTERNAL ALKYNES; RING EXPANSION; OXIME ESTERS; HETEROCYCLES; ANNULATION; METAL; ARYL; FUNCTIONALIZATION;
D O I：
10.1002/adsc.201601278
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An efficient synthesis of 2-substituted quinolines from readily available cyclopropanols and imidamides has been developed, where the cyclopropanol acts as a C-3 synthon. With the assistance of a bifunctional imidamide directing group, the reaction occurred via sequential C-H/C-C cleavage and C-C/C-N bond formation.
引用
收藏
页码：1620 / 1625
页数：6
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