Synthesis of 2-Substituted Quinolines via Rhodium(III)-Catalyzed C-H Activation of Imidamides and Coupling with Cyclopropanols

被引：57

作者：

Zhou, Xukai ^{[1
,2
]}

Qi, Zisong ^{[1
]}

Yu, Songjie ^{[1
]}

Kong, Lingheng ^{[1
,2
]}

Li, Yang ^{[3
]}

Tian, Wan-Fa ^{[3
]}

Li, Xingwei ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Ctr Organ Chem, Xian 710054, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 10期

关键词：

C-H activation; C-N bond formation; cyclopropanols; imidamides; 2-substituted quinolines; N BOND FORMATION; ONE-POT SYNTHESIS; INTERNAL ALKYNES; RING EXPANSION; OXIME ESTERS; HETEROCYCLES; ANNULATION; METAL; ARYL; FUNCTIONALIZATION;

D O I：

10.1002/adsc.201601278

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient synthesis of 2-substituted quinolines from readily available cyclopropanols and imidamides has been developed, where the cyclopropanol acts as a C-3 synthon. With the assistance of a bifunctional imidamide directing group, the reaction occurred via sequential C-H/C-C cleavage and C-C/C-N bond formation.

引用

页码：1620 / 1625

页数：6

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