Rhodium-catalyzed biheteroaryl-2-carbonitrile synthesis via double C-H activation

被引：10

作者：

Xu, Hui-Bei ^{[1
]}

Zhu, Yan-Ying ^{[1
]}

Yang, Jia-Hui ^{[1
]}

Chai, Xin-Yue ^{[1
]}

Dong, Lin ^{[1
]}

机构：

[1] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Res Ctr Drug Precis Ind Technol, Educ Minist,West China Sch Pharm, Chengdu 610041, Sichuan, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2019年 / 6卷 / 23期

关键词：

CROSS-COUPLING REACTIONS; ANNULATION CASCADE; RECENT PROGRESS; FUNCTIONALIZATION; HETEROARYLATION; ALKYNES; ACCESS; BONDS; ALKENYLATION; 1H-INDAZOLES;

D O I：

10.1039/c9qo01114e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhodium(iii)-catalyzed double C-H activation and in situ dealcoholization to generate useful biheteroaryl-2-carbonitriles have been well developed via a CDC mechanism, in which benzimidates act as both directing groups and the precursors of nitrile groups. This simple and atom-economical method synthesizes various biheteroaryl-2-carbonitrile derivatives, which could be further transformed to more complex compounds.

引用

页码：3864 / 3867

页数：4

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