Rhodium(III)-Catalyzed Atroposelective Synthesis of C-N Axially Chiral Naphthylamines and Variants via C-H Activation

被引：32

作者：

Wang, Peiyuan ^{[1
]}

Huang, Yaling ^{[1
]}

Jing, Jierui ^{[1
]}

Wang, Fen ^{[1
]}

Li, Xingwei ^{[1
]}

机构：

[1] Shaanxi Normal Univ SNNU, Sch Chem & Chem Engn, Xian 710062, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 13期

关键词：

CATALYTIC ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; SULFOXONIUM YLIDES; ANILIDES; ATROPISOMERS; CONSTRUCTION; ALLYLATION; LIGANDS; BINOL; BINAP;

D O I：

10.1021/acs.orglett.2c00686

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reported herein is the efficient and atroposelective construction of two categories of C-N atropisomers via rhodium(III)-catalyzed C-H activation of sulfoxonium ylides en route to [4+2] annulation with sterically hindered, electron-rich alkynes. This reaction proceeds with high regio- and enantioselectivity under redox-neutral conditions via a double-substrate activation strategy, providing a novel entry to C-N axially chiral 4-functionalized 1-naphthols.

引用

页码：2531 / 2535

页数：5

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