Regioselective ortho-acetoxylation/methoxylation of N-(2-benzoylphenyl)benzamides via substrate directed C-H activation

被引：25
|
作者：
Reddy, B. V. Subba [1 ]
Revathi, G. [1 ]
Reddy, A. Srinivas [1 ]
Yadav, J. S. [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Discovery Lab, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 45期
关键词：
Pd(II) catalysis; Hypervalent iodine; Benzamide; ortho-Acetoxylation/methoxylation; Aromatic C-H activation; CARBON-HYDROGEN BONDS; OXIDATIVE FUNCTIONALIZATION; CATALYZED ARYLATION; COUPLING REACTIONS; ACID DERIVATIVES; SP(2); OXIDANT; ACETOXYLATION; HETEROCYCLES; OXYGENATION;
D O I：
10.1016/j.tetlet.2011.08.098
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly regioselective ortho-acetoxylation of N-(2-benzoylphenyl)benzamides has been achieved using a catalytic amount of Pd(OAc)(2) (10 mol %) and a stoichiometric amount of Phl(OAc)(2) in a mixture of acetic anhydride and acetic acid via C-H activation to produce the corresponding 2-acetoxybenzamides in good yields. ortho-Methoxylation has been accomplished using methanol under similar conditions. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5926 / 5929
页数：4
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