Electrocatalytic C-H/N-H Coupling of 2′-Aminoacetophenones for the Synthesis of Isatins

被引：84

作者：

Qian, Peng ^{[1
,2
,3
]}

Su, Ji-Hu ^{[4
]}

Wang, Yukang ^{[1
,2
,3
]}

Bi, Meixiang ^{[1
,2
,3
]}

Zha, Zhenggen ^{[1
,2
,3
]}

Wang, Zhiyong ^{[1
,2
,3
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

[3] Univ Sci & Technol China, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Hefei 230026, Anhui, Peoples R China

[4] Univ Sci & Technol China, CAS Key Lab Microscale Magnet Resonance, Dept Modern Phys, Hefei 230026, Anhui, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 12期

基金：

中国国家自然科学基金;

关键词：

SUBSTITUTED ISATINS; ELECTROCHEMICAL SYNTHESIS; ORGANIC ELECTROSYNTHESIS; HALOFORM REACTION; MOLECULAR-OXYGEN; DOMINO APPROACH; METHYL KETONES; N-ARYLISATINS; OXIDATION; ACTIVATION;

D O I：

10.1021/acs.joc.7b00635

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2'-Aminoacetophenones undergo a C(sp(3))-H oxidation followed by intramolecular C-N bond formation by virtue of a simple electrochemical oxidation in the presence of n-Bu4NI, providing various isatins with moderate to good yields. The reaction intermediates were detected, and a radical-based pathway was proposed.

引用

页码：6434 / 6440

页数：7

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