Electrocatalytic C-H/N-H Coupling of 2′-Aminoacetophenones for the Synthesis of Isatins

被引：84
|
作者：
Qian, Peng [1 ,2 ,3 ]
Su, Ji-Hu [4 ]
Wang, Yukang [1 ,2 ,3 ]
Bi, Meixiang [1 ,2 ,3 ]
Zha, Zhenggen [1 ,2 ,3 ]
Wang, Zhiyong [1 ,2 ,3 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
[3] Univ Sci & Technol China, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Hefei 230026, Anhui, Peoples R China
[4] Univ Sci & Technol China, CAS Key Lab Microscale Magnet Resonance, Dept Modern Phys, Hefei 230026, Anhui, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 12期
基金：
中国国家自然科学基金;
关键词：
SUBSTITUTED ISATINS; ELECTROCHEMICAL SYNTHESIS; ORGANIC ELECTROSYNTHESIS; HALOFORM REACTION; MOLECULAR-OXYGEN; DOMINO APPROACH; METHYL KETONES; N-ARYLISATINS; OXIDATION; ACTIVATION;
D O I：
10.1021/acs.joc.7b00635
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2'-Aminoacetophenones undergo a C(sp(3))-H oxidation followed by intramolecular C-N bond formation by virtue of a simple electrochemical oxidation in the presence of n-Bu4NI, providing various isatins with moderate to good yields. The reaction intermediates were detected, and a radical-based pathway was proposed.
引用
收藏
页码：6434 / 6440
页数：7
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