Facile synthesis of annulated heterocyclic benzo[kl]acridine derivatives via one-pot N-H/C-H coupling

被引：8
|
作者：
Zagranyarski, Yulian [1 ,2 ]
Skabeev, Artem [1 ]
Ma, Yingjie [1 ]
Muellen, Klaus [1 ,3 ]
Li, Chen [1 ]
机构：
[1] Max Planck Inst Polymer Res, Ackermannweg 10, D-55128 Mainz, Germany
[2] Sofia Univ St Kliment Ohridski, Fac Chem & Pharm, 1 James Bourchier Ave, Sofia 1164, Bulgaria
[3] Johannes Gutenberg Univ Mainz, Inst Phys Chem, Duesbergweg 10-14, D-55128 Mainz, Germany
来源：
ORGANIC CHEMISTRY FRONTIERS | 2016年 / 3卷 / 11期
关键词：
CARBAZOLES; ACTIVATION; INDOLES; NITRO; REDUCTION; KETONES;
D O I：
10.1039/c6qo00371k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient N-H/C-H one-pot coupling method for the preparation of benzo[kl]acridines has been developed based on palladium-catalyzed domino synthesis. Using commercially available starting materials such as dihalonaphthalenes and diphenylamines, and combining amination with catalysts for C-H activation, up to 95% overall yield can be achieved.
引用
收藏
页码：1520 / 1523
页数：4
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