Repeatability and reproducibility of anterior ocular biometric measurements with 2-dimensional and 3-dimensional optical coherence tomography

PURPOSE To evaluate the repeatability and reproducibility of central corneal thickness (CCT), anterior chamber depth (ACD), and anterior chamber width (ACW) measurements using 3-dimensional (3-D) corneal and anterior segment optical coherence tomography (CAS-OCT) and 2-dimensional (2-D) anterior segment OCT (AS-OCT) SETTING Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan DESIGN Nonrandomized clinical trial METHODS The CCT, ACD, and ACW were measured in normal eyes using a prototype 3-D swept-source CAS-OCT device and a 2-D time-domain AS-OCT device (Visante) The coefficient of repeatability and reproducibility and the intraclass correlation coefficient (ICC) were calculated to evaluate the repeatability and reproducibility of the measurements RESULTS Eighty-five eyes (85 subjects) were evaluated The mean CCT measurement was 557 5 mu m +/- 40 5 (SD) with CAS-OCT and 556 4 +/- 39 4 mu m with AS-OCT, the mean ACD measurement, 3 13 +/- 0 40 mm and 3 16 +/- 0 39 mm, respectively, and the mean ACW, 11 80 + 0 47 mm and 11 79 + 0 49 mm, respectively There was no statistically significant difference in CCT or AC,W measurements between the 2 devices (P> 05, Wilcoxon signed rank test) Although the ACD measurements were significantly different (P< 0001), the difference was small (0 03 mm) Significant linear correlations were found between the measurements of the 2 devices (P< 0(101) The ICC was greater than 0 99 for CAS-OCT and greater than 0 96 for AS-OCT CONCLUSION Corneal and anterior segment OCT and AS-OCT provided comparable and well-correlated anterior ocular biometric measurements with sufficient repeatability and reproducibility