Copper-Catalyzed Tandem C-N Bond Formation: An Efficient Annulative Synthesis of Functionalized Cinnolines

被引：61
|
作者：
Ball, Catherine J. [1 ]
Gilmore, Jeremy [2 ]
Willis, Michael C. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
[2] Eli Lilly & Co Ltd, Lilly Res Ctr, Erl Wood Manor, Windlesham GU20 6PH, Surrey, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 23期
基金：
英国工程与自然科学研究理事会;
关键词：
annulation; cinnolines; copper catalysis; heterocycles; tandem processes; NITROGEN-HETEROCYCLES; ANTICANCER AGENTS; FACILE SYNTHESIS; DERIVATIVES; ANTIFUNGAL; AMINATION; ALKENYL; LIGANDS; ROUTE;
D O I：
10.1002/anie.201201529
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cinn-tillating synthesis: The combination of a readily available copper catalyst, a simple hydrazide nucleophile, and established difunctionalized building blocks provides a new, flexible route to an under-developed class of aromatic heterocycles, cinnolines (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：5718 / 5722
页数：5
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